Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Bone Loss Cancer Mediated

  • Andrew C. W. Zannettino
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_679-2



Metastasis describes the spread of cancer from its site of origin (the “primary site”) to another location in the body (the “secondary site”). The bone is the most frequent site affected by metastatic cancer. While any type of cancer can spread to the bone, metastatic bone disease is most commonly associated with cancers whose primary origin is the breast, prostate, or lung. Although less common, bone metastases are also associated with cancers arising in the thyroid, kidney, stomach, uterus, colon, bladder, and rectum (Table 1). Metastasis of cancer to the bone often results in significant skeletal morbidity which manifests as severe bone pain, pathologic fractures, spinal cord compression, and life-threatening hypercalcemia.
Table 1

Incidence of primary tumors...


Multiple Myeloma Bone Metastasis Bone Matrix Connective Tissue Growth Factor Vicious Cycle 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Myeloma Research Laboratory, School of Medicine, Faculty of Health SciencesUniversity of AdelaideAdelaideAustralia