Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Prostate Cancer Stem Cells

  • Zhu A. Wang
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6785-2

Definition

Cancer stem cells (CSCs) are rare cancer cells within tumors that manifest normal stem cell properties, namely, the abilities of self-renewal and differentiation into all other types of cancer cells. Cancers harboring CSCs are organized hierarchically with the CSCs driving the growth of the tumor and their differentiated progeny having limited tumorigenic potential. The CSC theory has clinical implications because conventional therapies may kill differentiated cancer cells that constitute the bulk of the tumor but spare the CSCs, which may be particularly resistant. To prevent relapse of the disease, developing novel therapies specifically targeting CSCs is important. First identified in leukemias, CSCs are now prospectively isolated from a variety of solid tumors, although their existence in solid tumors is still controversial due to possible underestimations of tumorigenicity of non-CSCs. In prostate cancer, it is postulated that prostate cancer stem cells (PCSCs) are...

Keywords

Prostate Cancer Androgen Receptor Adult Stem Cell Prostate Cancer Cell Line Prostate Cancer Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Genetics and DevelopmentColumbia University Medical Center, Herbert Irving Comprehensive Cancer CenterNew YorkUSA