Head and Neck Cancer
Head and neck cancer (HNC) encompasses any cancerous/malignant growth in the head or neck region extending to the level of the clavicles inferiorly and generally excluding intracranial and spinal cancers. The vast majority of HNC is caused by squamous cell carcinoma, and this will be the focus of our discussion keeping in mind that many other tumor types exist.
The diversity of tissues in the head and neck anatomic region results in a broad range of tumor types and conditions. Head and neck cancers are classified based on their anatomic location and histopathologic tumor type, and squamous cell carcinoma accounts for 90–95 %.
Head and neck cancers are the fifth most common cancer type and cause for cancer-related deaths and affect approximately 500,000–600,000 people per year worldwide. Incidence varies depending on the geographic location likely due to the prevalence of risk factors and ethnic and genetic differences among populations. For...
KeywordsEpidermal Growth Factor Receptor Human Papilloma Virus Adenoid Cystic Carcinoma Epidermal Growth Factor Receptor Gene Transoral Laser Microsurgery
Department of Otolaryngology, University of Kansas Medical Center, and University of Kansas Cancer Center’s CCSG (1-P30-CA168524-02) were the funding sources.
- Lai SY, Koppikar P, Thomas SM, Childs EE, Egloff AM, Seethala RR, Branstetter BF, Gooding WE, Muthukrishnan A, Mountz JM, Lui VW, Shin DM, Agarwala SS, Johnson R, Couture LA, Myers EN, Johnson JT, Mills G, Argiris A, Grandis JR (2009) Intratumoral epidermal growth factor receptor antisense DNA therapy in head and neck cancer: first human application and potential antitumor mechanisms. J Clin Oncol 27:1235–1242PubMedPubMedCentralCrossRefGoogle Scholar
- Sen M, Thomas SM, Kim S, Yeh JI, Ferris RL, Johnson JT, Duvvuri U, Lee J, Sahu N, Joyce S, Freilino ML, Shi H, Li C, Ly D, Rapireddy S, Etter JP, Li PK, Wang L, Chiosea S, Seethala RR, Gooding WE, Chen X, Kaminski N, Pandit K, Johnson DE, Grandis JR (2012) First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy. Cancer Discov 2:694–705PubMedPubMedCentralCrossRefGoogle Scholar