Skip to main content
SpringerLink
Log in

Breast Cancer Multistep Development

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

  • 58 Accesses

Definition

A multistep development of breast cancer involves increasingly abnormal stages during breast cancer progression as illustrated in Fig. 1.

Fig. 1
figure 1

Schematic representation of the multistep model of breast cancer development. These steps can be defined as a series of increasingly abnormal stages including hyperplasia, atypical hyperplasia, carcinoma in situ, invasive carcinoma, and metastatic breast cancer

Full size image

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57–70

    Article  PubMed  CAS  Google Scholar 

  • Polyak K (2001) On the birth of breast cancer. Biochim Biophys Acta 1552:1–13

    PubMed  CAS  Google Scholar 

  • Sorlie T, Perou CM, Tibshirani R et al (2001) Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 98:10869–10874

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Tang P, Hajdu SI, Lyman GH (2007) Ductal carcinoma in situ: a review of recent advances. Curr Opin Obstet Gynecol 19:63–67

    Article  PubMed  Google Scholar 

  • Tsikitis VL, Chung MA (2006) Biology of ductal carcinoma in situ classification based on biologic potential. Am J Clin Oncol 29:305–310

    Article  PubMed  Google Scholar 

  • Xu J, Acharya S, Sahin O et al. (2015) 14–3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2. Cancer Cell 27:177–192.

    Article  PubMed  CAS  Google Scholar 

See Also

  • (2012) Acetylation. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 17. doi:10.1007/978-3-642-16483-5_24

    Google Scholar 

  • (2012) Allelic loss. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 137. doi:10.1007/978-3-642-16483-5_186

    Google Scholar 

  • (2012) Basement membrane. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 349. doi:10.1007/978-3-642-16483-5_537

    Google Scholar 

  • (2012) Carcinoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 657. doi:10.1007/978-3-642-16483-5_848

    Google Scholar 

  • (2012) Chromatin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 825. doi:10.1007/978-3-642-16483-5_1125

    Google Scholar 

  • (2012) Deletion. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1080. doi:10.1007/978-3-642-16483-5_1553

    Google Scholar 

  • (2012) Differentiation. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1113. doi:10.1007/978-3-642-16483-5_1616

    Google Scholar 

  • (2012) Epithelial cell. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 1291–1292. doi:10.1007/978-3-642-16483-5_1958

    Google Scholar 

  • (2012) Gain-of-function mutation. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1489. doi:10.1007/978-3-642-16483-5_2303

    Google Scholar 

  • (2012) Histones. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1706. doi:10.1007/978-3-642-16483-5_2762

    Google Scholar 

  • (2012) HER2. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1678. doi:10.1007/978-3-642-16483-5_2676

    Google Scholar 

  • (2012) HOX. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1739. doi:10.1007/978-3-642-16483-5_2819

    Google Scholar 

  • (2012) Intravasation. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1901. doi:10.1007/978-3-642-16483-5_3125

    Google Scholar 

  • (2012) Loss-of-function mutation. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2076. doi:10.1007/978-3-642-16483-5_3414

    Google Scholar 

  • (2012) Mutation. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2412. doi:10.1007/978-3-642-16483-5_3911

    Google Scholar 

  • (2012) Myoepithelial cells. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2440. doi:10.1007/978-3-642-16483-5_3943

    Google Scholar 

  • (2012) P53. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2747. doi:10.1007/978-3-642-16483-5_4331

    Google Scholar 

  • (2012) Proliferation. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3004. doi:10.1007/978-3-642-16483-5_4766

    Google Scholar 

  • (2012) Proto-oncogenes. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 3107–3108. doi:10.1007/978-3-642-16483-5_6656

    Google Scholar 

  • (2012) Stroma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3541. doi:10.1007/978-3-642-16483-5_5532

    Google Scholar 

  • (2012) Translocation. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3773. doi:10.1007/978-3-642-16483-5_5942

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA

    Dihua Yu & Jing Lu

Authors
  1. Dihua Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jing Lu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dihua Yu .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this entry

Cite this entry

Yu, D., Lu, J. (2014). Breast Cancer Multistep Development. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_6655-2

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-27841-9_6655-2

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Search

Navigation