Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Anthracyclines

  • Manfred Schwab
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6646-2

Definition

Anthracyclines, consisting of daunosamine and tetra-hydro-naphthacene-dione, are a class of chemotherapeutic agents used to treat many cancers. These compounds exhibit cytotoxic activity through intercalation into DNA, inhibition of topoisomerase II, and the production of free radicals. In cancer chemotherapy with anthracyclines, the serious problem is the side effects, cardiotoxicity and bone marrow depression, and the emergence of drug resistance.

Cross-References

Keywords

Bone Marrow Free Radical Cancer Research Drug Resistance Chemotherapeutic Agent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.German Cancer Research Center (DKFZ)HeidelbergGermany