Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Manfred Schwab
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6646-2


Anthracyclines, consisting of daunosamine and tetra-hydro-naphthacene-dione, are a class of chemotherapeutic agents used to treat many cancers. These compounds exhibit cytotoxic activity through intercalation into DNA, inhibition of topoisomerase II, and the production of free radicals. In cancer chemotherapy with anthracyclines, the serious problem is the side effects, cardiotoxicity and bone marrow depression, and the emergence of drug resistance.



Bone Marrow Free Radical Cancer Research Drug Resistance Chemotherapeutic Agent 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.German Cancer Research Center (DKFZ)HeidelbergGermany