Definition
Active specific immunmotherapy (immunotherapy) of cancer endeavors to direct the host’s own immune system against an antigen expressed by tumor cells to create an immune response that will destroy the established tumor. The same immune response induced in an adjuvant setting targets and intends to eliminate isolated disseminated tumor cells (micrometastasis) to prevent disease recurrence and to create a state of immune surveillance (immune surveillance of tumors) that will eliminate tumor cells as they arise. Passive immunotherapy uses monoclonal antibodies (MAbs; monoclonal antibody therapy) Monoclonal Antibodies for Cancer Therapy that bind to receptors or antigens on the tumor cell surface blocking receptor-ligand interactions and recruiting immune effector cells against the tumor. Trastuzumab (Herceptin®), a monoclonal antibody to human epidermal growth factor receptor 2 (HER2; HER2/neu; epidermal growth factor inhibitors), is already part of the standard treatment of...
Keywords
- Breast Cancer
- Vascular Endothelial Growth Factor
- Metastatic Breast Cancer
- Cancer Vaccine
- Epithelial Growth Factor Receptor
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
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See also
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(2012) MAGE. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2135. doi:10.1007/978-3-642-16483-5_6375
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(2012) Transgenic mice. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3763. doi:10.1007/978-3-642-16483-5_5921
(2012) Tumor-associated antigen. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 3807–3808. doi:10.1007/978-3-642-16483-5_6017
(2012) Tyrosine kinase. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3822. doi:10.1007/978-3-642-16483-5_6079
(2012) Vaccine therapy. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3879. doi:10.1007/978-3-642-16483-5_6147
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von Mensdorff-Pouilly, S. (2014). Breast Cancer Immunotherapy. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_6630-2
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DOI: https://doi.org/10.1007/978-3-642-27841-9_6630-2
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