Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Breast Cancer Stem Cells

  • Pranela Rameshwar
  • Shyam Patel
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6628-3

Synonyms

Definition

Breast cancer stem cells are self-renewing cells that form new tumor cells. They represent a small fraction of cells that are resistant to chemotherapy and radiation therapy. Chemotherapeutic agents with some effect on breast cancer stem cells include 5-fluorouracil, platinum-based agents (platinum complexes), taxol, and doxorubicin. The frequency of tumor stem cells varies, depending on tumor type. However, <5 % of tumor cells may exhibit stem-like phenotype with enhanced tumorigenicity as compared with the molecularly heterogeneous population without stem-like property.

Characteristics

Origins of the Breast Cancer Stem Cells

Tumors of many solid organs contain a population of cells with stem-like phenotype. Much evidence has accumulated on breast cancer stem cells, including expression of stem cell markersin heterogeneous populations of breast cancer cells. Nestin, an...

Keywords

Breast Cancer Disseminate Tumor Cell Breast Cancer Stem Cell ALDH1 Expression Endogenous Stem Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Medicine-Hematology/OncologyRutgers, New Jersey Medical SchoolNewarkUSA
  2. 2.Standford UniversityPalo AltoUSA