Breast Cancer Stem Cells
Breast cancer stem cells are self-renewing cells that form new tumor cells. They represent a small fraction of cells that are resistant to chemotherapy and radiation therapy. Chemotherapeutic agents with some effect on breast cancer stem cells include 5-fluorouracil, platinum-based agents (platinum complexes), taxol, and doxorubicin. The frequency of tumor stem cells varies, depending on tumor type. However, <5 % of tumor cells may exhibit stem-like phenotype with enhanced tumorigenicity as compared with the molecularly heterogeneous population without stem-like property.
Origins of the Breast Cancer Stem Cells
Tumors of many solid organs contain a population of cells with stem-like phenotype. Much evidence has accumulated on breast cancer stem cells, including expression of stem cell markersin heterogeneous populations of breast cancer cells. Nestin, an...
KeywordsBreast Cancer Disseminate Tumor Cell Breast Cancer Stem Cell ALDH1 Expression Endogenous Stem Cell
- Tanei T, Morimoto K, Shimazu K, Kim SJ, Tanji Y, Taguchi T, Tamaki Y, Noguchi S (2009) Association of breast cancer stem cells identified by aldehyde dehydrogenase 1 expression with resistance to sequential Paclitaxel and epirubicin-based chemotherapy for breast cancers. Clin Cancer Res 15:4234–4241PubMedCrossRefGoogle Scholar