Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Colon Cancer Molecular and Targeted Experimental Therapy

  • Yun Dai
  • George Wilson
  • Liang Qiao
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6589-3

Definition

Colorectal cancer (CRC) is the third most common cancer and the third leading cause of cancer death in the USA. CRC incidence rates have rapidly increased in several regions where the incidence was historically low, including parts of East Asia and Eastern Europe. In 2014, it was estimated that 136,830 new cases and 50,310 deaths have occurred in the USA and over 1.2 million new cases and some 600,000 deaths have occurred worldwide. The prognosis of CRC declines rapidly with the advanced staging. According to the American Joint Committee on Cancer (AJCC) staging system, the overall 5-year survival of patients with stage I CRC was greater than 90 %, whereas that of the stage IV was less than 10 %. Unfortunately, surgical resection is not suitable for the vast majority of CRC patients who have metastatic disease. As a result, more effective treatment approaches for CRC are needed.

Characteristics

Molecularly Targeted Therapies

Advances in the understanding of cellular and...

Keywords

Vascular Endothelial Growth Factor Hepatocyte Growth Factor mCRC Patient Adoptive Cell Therapy Extrinsic Apoptosis Pathway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Notes

Acknowledgment

This work was partially supported by the Robert W. Storr Bequest to the Sydney Medical Foundation, University of Sydney, a National Health and Medical Research Council of Australia (NHMRC) Project grant to LQ (ID: APP1047417), and two Cancer Council NSW grants to LQ (ID: APP1070076) and LH (ID: APP1069733).

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of GastroenterologyPeking University First HospitalBeijingChina
  2. 2.Storr Liver Centre, Westmead Millennium Institute for Medical ResearchUniversity of Sydney at Westmead HospitalWestmeadAustralia