Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Bispecific Antibodies

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_658-2

Definition

Bispecific antibodies are antibodies possessing antigen-binding sites with specificity for two different structures (dual specificity).

Characteristics

Bispecific antibodies are molecules able to simultaneously bind to two different epitopes on the same or different antigens. Bispecific antibodies act as mediators or adaptors bringing two different structures into close contact. In cancer therapy, possible applications include the retargeting of effector molecules (e.g., radionuclides, drugs, enzymes, cytokines), effector cells (e.g., cytotoxic T lymphocytes, natural killer cells), or carrier systems (e.g., drug-loaded liposomes, genetic vehicles) to tumor-associated target sites, such as tumor cells, tumor stroma cells, and extracellular components as well as cells and structures associated with the tumor vasculature. Thus, potential applications of bispecific antibodies cover the areas of immunotherapy, chemotherapy, radiotherapy ( radioimmunotherapy), and gene therapy....

Keywords

Effector Cell Somatic Hybridization Bispecific Antibody Costimulatory Signal Trigger Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Kontermann RE (2006) Recombinant bispecific antibodies for cancer therapy. Acta Pharmacol Sin 26:1–9CrossRefGoogle Scholar
  2. Kufer P, Lutterbuse R, Baeuerle PA (2004) A revival of bispecific antibodies. Trends Biotechnol 22:38–44CrossRefGoogle Scholar
  3. Müller D, Kontermann RE (2007) Bispecific antibodies. In: Dübel S (ed) Handbook of therapeutic antibodies, vol 2. Weinheim, Wiley, pp 345–378CrossRefGoogle Scholar
  4. Peipp M, Valerius T (2002) Bispecific antibodies targeting cancer cells. Biochem Soc Trans 30:507–511CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Institute of Cell Biology and ImmunologyUniversity of StuttgartStuttgartGermany