Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Colon Cancer Pathology of Hereditary Forms

  • Zoran Gatalica
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6555-2

Definition

Approximately 5 % of all colorectal carcinomas are due to a defined single genetic defect causing hereditary disease. Gross and microscopic pathologic examination of the resection or biopsy specimen can help identify an unsuspected case of hereditary colorectal carcinoma due to the characteristic morphologic findings seen in some syndromes. Additional immunohistochemical and molecular studies can then provide a definitive diagnosis. Furthermore, due to the germline nature of mutations in these syndromes, various extracolonic manifestations may be the first sign of the disease, and knowledge of such associations can greatly improve the quality of care for these patients.

Characteristics

Colorectal Cancer in Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer)

The most common form of hereditary colorectal carcinoma is Lynch syndrome (synonymhereditary nonpolyposis colorectal cancer, HNPCC) caused by inactivating mutation(s) in genes for DNA mismatch repair (MMR)...

Keywords

Papillary Thyroid Carcinoma Familial Adenomatous Polyposis Lynch Syndrome Desmoid Tumor Polyposis Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Atard TM, Young RJ (2006) Diagnosis and management of gastrointestinal polyps. Gastroenterol Nurs 29:16–22CrossRefGoogle Scholar
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  4. Gatalica Z, Torlakovic E (2008) Pathology of the hereditary colorectal carcinoma. Fam Cancer 7:15–26CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of PathologyCreighton University School of MedicineOmahaUSA