Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Renal Cancer Targeted Therapies with Tyrosine Kinase Inhibitors

  • Egbert Oosterwijk
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6327-2

Definition

Tyrosine kinase inhibitors (TKIs) are drugs that interfere with cell communication and growth and may prevent tumor growth.

Characteristics

Until recently, patients with metastatic renal cell carcinoma (RCC) were treated with interferon-α, interleukin 2, or combinations thereof. Unfortunately, these agents had limited efficacy and response rates remained low (∼10–15 %). For patients not responding to first-line cytokine therapy, no option for treatment was available. With our increased understanding of the molecular defects that are at the heart of RCC subtypes, new treatment modalities specifically targeting these pathways have been explored. This has led to a revolution in the treatment of RCC. Nevertheless, although improvement is significant, it is still modest and mostly concerns improvement of 2–6 months of progression-free survival.

The most prominent feature of clear-cell RCC (renal carcinoma) is the upregulation of the angiogenic molecule vascular endothelial growth...

Keywords

Vascular Endothelial Growth Factor Renal Cell Carcinoma Tyrosine Kinase Inhibitor Vascular Endothelial Growth Factor Receptor Metastatic Renal Cell Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Laboratory of Experimental UrologyUniversity Medical Centre NijmegenNijmegenThe Netherlands