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Zonula Occludens Protein-1

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

  • 61 Accesses

Synonyms

Tight junction protein-1; TJP-1; ZO-1

Definition

The zonula occludens (ZO-1) protein-1 is a membrane-associated component of both tight junctions (TJs) and adherens junctions (AJs) found at the site of cell-cell contact. Functionally, ZO-1 is an intracellular adaptor protein and is known to interact with claudins, occludin, cadherins, actin cytoskeleton, and downstream signaling pathways and transcription factors (such as ZONAB).

Characteristics

In order for organs to perform their diverse functions, the constituent cells that make up a tissue must be able to arrange themselves in an organized fashion. The complex architecture of a given tissue is regulated by the differential expression of cell-cell adhesion molecules. Epithelial cells adhere to each other through a set of intercellular junctions that consist of adherens junctions (AJs), tight junctions (TJs), and desmosomes. These different types of junctions perform discrete adhesion and organizational and transport...

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References

  • Gonzalez-Mariscal L, Betanzos A, Avila-Flores A (2000) MAGUK proteins: structure and role in the tight junction. Semin Cell Dev Biol 11(4):315–324

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  • Kavanagh E, Buchert M, Tsapara A et al (2006) Functional interaction between the ZO-1-interacting transcription factor ZONAB/DbpA and the RNA processing factor symplekin. J Cell Sci 119:5098–5105

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  • Smalley KS, Brafford PA, Haass NK et al (2005) Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion and adhesion. Am J Pathol 166:1541–1554

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Author information

Authors and Affiliations

  1. The Wistar Institute, Philadelphia, PA, USA

    Keiran S. M. Smalley & Meenhard Herlyn

Authors
  1. Keiran S. M. Smalley
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  2. Meenhard Herlyn
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Corresponding author

Correspondence to Keiran S. M. Smalley .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2015 Springer-Verlag Berlin Heidelberg

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Smalley, K.S.M., Herlyn, M. (2015). Zonula Occludens Protein-1. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_6305-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_6305-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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