Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Bioavailability

  • Manfred Schwab
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_626-2

Definition

Bioavailability of Nutrients

Refers to the fraction of a mineral nutrient intake that is biologically available to meet the essential metabolic and/or structural functions associated with that mineral nutrient in the body. Bioavailability incorporates the concepts of absorption, distribution, metabolic transformation (where necessary to meet biological function), and excretion. In some circumstances the main component of bioavailability is absorption across the gastrointestinal wall, so that sometimes the term bioavailability may be used interchangeably with absorption.

Bioavailability of Drugs

Refers to the percentage of drug that is detected in the systemic circulation after its administration. Losses can be attributed to an inherent lack of absorption/passage into the systemic circulation and/or to metabolic clearance. Detection of drug can be accomplished pharmacodynamically or pharmacokinetically. Oral bioavailability is associated with orally administered drugs.

Cross-References...

Keywords

Cancer Research Nutrient Intake Systemic Circulation Biological Function Structural Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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See Also

  1. (2012) Pharmacodynamics. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2840. doi: 10.1007/978-3-642-16483-5_4495Google Scholar
  2. (2012) Pharmacokinetics. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2845. doi: 10.1007/978-3-642-16483-5_4500Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.German Cancer Research Center (DKFZ)HeidelbergGermany