Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Withaferin A

  • Chendil Damodaran
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6253-2

Synonyms

WA

Definition

The natural product Withaferin A (WA) is an important bioactive component of Withania somnifera (WS), a medicinal plant of the Solanaceae family that is used in the Indian Ayurvedic medical system, as well as many other indigenous medical practices. A structural analysis of WA indicates that it is a highly oxygenated C-28 ergostane-type steroid with a 22, 26-lactone and a 1-oxo-group (Fig. 1).

Keywords

Prostate Cancer Prostate Cancer Cell Ehrlich Ascites Carcinoma Mouse Ehrlich Ascites Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Kaileh M et al (2007) Withaferin A strongly elicits I{kappa}B kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity. J Biol Chem 282(7):4253–4264CrossRefPubMedGoogle Scholar
  2. Shohat B et al (1976) The effect of withaferin A on human peripheral blood lymphocytes. An electron-microscope study. Cancer Lett 2(2):63–70CrossRefPubMedGoogle Scholar
  3. Srinivasan S et al (2007) Par-4-dependent apoptosis by the dietary compound withaferin A in prostate cancer cells. Cancer Res 67(1):246–253CrossRefPubMedGoogle Scholar
  4. Yang H, Shi G, Dou QP (2007) The tumor proteasome is a primary target for the natural anticancer compound Withaferin A isolated from “Indian winter cherry”. Mol Pharmacol 71(2):426CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.University of LouisvilleLouisvilleUSA