Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Withaferin A

  • Chendil Damodaran
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6253-2




The natural product Withaferin A (WA) is an important bioactive component of Withania somnifera (WS), a medicinal plant of the Solanaceae family that is used in the Indian Ayurvedic medical system, as well as many other indigenous medical practices. A structural analysis of WA indicates that it is a highly oxygenated C-28 ergostane-type steroid with a 22, 26-lactone and a 1-oxo-group (Fig. 1).


Prostate Cancer Prostate Cancer Cell Ehrlich Ascites Carcinoma Mouse Ehrlich Ascites Carcinoma 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.University of LouisvilleLouisvilleUSA