Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Vitamin D

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6207-2

Definition

The biologically most active form of vitamin D, 1α,25-dihydroxy-vitamin D3, and many synthetic analogs exert antiproliferative actions on different cancer cell types, most typically breast, colon, and prostate. Recent clinical studies indicate a potentially important role for vitamin D in the prevention and treatment of cancer.

Characteristics

1α,25-dihydroxy-vitamin D3(1,25D), or calcitriol, the biologically most active form of vitamin D, is essential to bone and mineral metabolism. 1,25D deficiency has been traditionally associated with bone diseases characterized by decreased bone mass and reduced mineralization, such as rickets, osteomalacia, and osteoporosis. In addition to its well-known actions on bone and calcium homeostasis, this secosteroid hormone exerts a number of effects on many different target organs and systems. 1,25D actions include regulation of cell cycle, cell proliferation, and differentiation in breast, colon, and prostate, among others. 1,25D binds...

Keywords

Synthetic Analog Inhibit Cancer Cell Proliferation Promote Cell Cycle Arrest Retinoblastoma Gene Product Impaired Bone Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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See Also

  1. (2012) Autocrine. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 311. doi:10.1007/978-3-642-16483-5_468Google Scholar
  2. (2012) Carboplatin. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 641. doi:10.1007/978-3-642-16483-5_833Google Scholar
  3. (2012) Cell Cycle. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 737. doi:10.1007/978-3-642-16483-5_994Google Scholar
  4. (2012) C-Myc. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 886. doi:10.1007/978-3-642-16483-5_1232Google Scholar
  5. (2012) Glioma. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1557. doi:10.1007/978-3-642-16483-5_2423Google Scholar
  6. (2012) Hypercalcemia. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1780. doi:10.1007/978-3-642-16483-5_2903Google Scholar
  7. (2012) Paracrine. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2783. doi:10.1007/978-3-642-16483-5_4380Google Scholar
  8. (2012) Transcription Factor. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3752. doi:10.1007/978-3-642-16483-5_5901Google Scholar
  9. (2012) Vitamin D Receptor. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3928. doi:10.1007/978-3-642-16483-5_6208Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of BiochemistryUniversity of California-RiversideRiversideUSA