Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

V(D)J Recombination

  • Markus Müschen
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6171-2

Synonyms

Definition

Surface immunoglobulin (expressed on B lymphocytes) and T cell receptors (expressed on T lymphocytes) represent the central molecules for antigen recognition in adaptive immune responses. Variable (V), diversity (D), and joining (J) gene segments, which together encode immunoglobulin or T cell receptor variable chains, are present in every somatic cell. However, in order to acquire coding capacity, V, D, and J gene segments need to be assembled in a functional configuration. The mechanism for the assembly of V, D, and J gene segments, termed V(D)J recombination, represents a unique capacity of both B and T lymphocytes.

Characteristics

More than 30 years ago, Hozumi and Tonegawa discovered that immunoglobulin genes in B lymphocytes as opposed to any other somatic cell type undergo a complex rearrangement process in order to assemble a functional...

Keywords

Acute Lymphoblastic Leukemia Mantle Cell Lymphoma Gene Rearrangement Gene Segment Recombination Signal Sequence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Leukemia and Lymphoma Program, Norris Comprehensive Cancer CenterUniversity of Southern CaliforniaLos AngelesUSA