Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

V(D)J Recombination

  • Markus Müschen
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6171-2



Surface immunoglobulin (expressed on B lymphocytes) and T cell receptors (expressed on T lymphocytes) represent the central molecules for antigen recognition in adaptive immune responses. Variable (V), diversity (D), and joining (J) gene segments, which together encode immunoglobulin or T cell receptor variable chains, are present in every somatic cell. However, in order to acquire coding capacity, V, D, and J gene segments need to be assembled in a functional configuration. The mechanism for the assembly of V, D, and J gene segments, termed V(D)J recombination, represents a unique capacity of both B and T lymphocytes.


More than 30 years ago, Hozumi and Tonegawa discovered that immunoglobulin genes in B lymphocytes as opposed to any other somatic cell type undergo a complex rearrangement process in order to assemble a functional...


Acute Lymphoblastic Leukemia Mantle Cell Lymphoma Gene Rearrangement Gene Segment Recombination Signal Sequence 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Leukemia and Lymphoma Program, Norris Comprehensive Cancer CenterUniversity of Southern CaliforniaLos AngelesUSA