Vascular Targeting Agents
Vascular targeting agents (VTAs) are primarily cancer therapies that are specifically designed to target the vasculature of tumors and as a consequence will inhibit tumor growth and development. They may also be used to treat other pathophysiological conditions in which the tissue vasculature plays a role.
In cancer, the vascular supply to tumors is critical. For most solid tumors to grow beyond a size of a few millimeters, it is necessary for them to develop their own functional blood supply, which they do from the already established normal tissue vasculature by a process called angiogenesis. This process begins with the tumor cells secreting various angiogenic growth factors. These factors are upregulated by different environmental changes such as hypoxia, loss of tumor suppressor function, or oncogeneactivation. Of these angiogenic factors,...
KeywordsVascular Endothelial Growth Factor Ionize Radiation Therapy Vinca Alkaloid Arsenic Trioxide Corticosteroid Hormone
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