Uterine Leiomyoma, Clinical Oncology
Uterine leiomyomas are benign neoplasms, composed of smooth muscle cells with variable amounts of fibrous stroma.
Leiomyomas are usually found in the myometrium of the uterine corpus; however, they can also originate in the smooth muscle organs. They are composed of smooth muscle and extracellular matrix (collagen, proteoglycan, fibronectin).
Uterine leiomyomas are the most common neoplasms of the female pelvis. They occur in ∼20–25 % of women of reproductive age, but careful pathologic inspection of the uterus reveals that they are present in more than 80 % of women. The neoplasm is more frequently found in the fourth and fifth decades of life and most commonly in patients of African descent. Age-standardized rates by race were 8.9 new cases per 1,000 women per year for Caucasian women and 30.6 new cases per 1,000 women per year for black women. Hispanic and Asian...