Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Uterine Leiomyoma, Clinical Oncology

  • Keisuke Kurose
  • Tsutomu Araki
  • Mitsuru Emi
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6137-3



Uterine leiomyomas are benign neoplasms, composed of smooth muscle cells with variable amounts of fibrous stroma.


Leiomyomas are usually found in the myometrium of the uterine corpus; however, they can also originate in the smooth muscle organs. They are composed of smooth muscle and extracellular matrix (collagen, proteoglycan, fibronectin).


Uterine leiomyomas are the most common neoplasms of the female pelvis. They occur in ∼20–25 % of women of reproductive age, but careful pathologic inspection of the uterus reveals that they are present in more than 80 % of women. The neoplasm is more frequently found in the fourth and fifth decades of life and most commonly in patients of African descent. Age-standardized rates by race were 8.9 new cases per 1,000 women per year for Caucasian women and 30.6 new cases per 1,000 women per year for black women. Hispanic and Asian...


GnRH Agonist Uterine Artery Embolization Recurrent Pregnancy Loss Medroxyprogesterone Acetate Uterine Leiomyoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.


  1. Ashar HR, Fejzo MS, Tkachenko A et al (1995) Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell 82:57–65CrossRefPubMedGoogle Scholar
  2. Barbieri RL (1999) Ambulatory management of uterine leiomyomata. Clin Obstet Gynecol 42:196–205CrossRefPubMedGoogle Scholar
  3. Kurose K, Mine N, Doi D et al (2000) Novel gene fusion of COX6C at 8q22–23 to HMGIC at 12q15 in a uterine leiomyoma. Genes Chromosomes Cancer 27:303–307CrossRefPubMedGoogle Scholar
  4. Schoenmakers EF, Wanschura S, Mols R et al (1995) Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumors. Nat Genet 10:436–444CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Keisuke Kurose
    • 1
  • Tsutomu Araki
    • 1
  • Mitsuru Emi
    • 1
  1. 1.Departments of Obstetrics and GynecologyNippon Medical SchoolKawasaki and TokyoJapan