Synonyms
Definition
The urothelium covers the inner surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. Usually it is composed of three to seven layers of cells. The luminal surface of the superficial cells is covered with an asymmetric unit membrane, which functions as the permeability barrier between urine and blood. Nearly 90 % of the urothelial carcinoma arises in the bladder and renal pelvic and ureteral carcinomas account for only approximately 7 % of the total. Worldwide, there are approximately 336,000 new cases of urothelial carcinoma and 132,000 deaths annually.
Characteristics
Morphological and pathological characteristics of urothelial carcinoma, mainly bladder carcinomas (bladder cancer), are a combination of papillary superficial carcinoma and nodular invasive carcinoma. Primary and/or associated urothelial carcinoma in situ (CIS) is occasionally seen. Papillary...
This is a preview of subscription content, log in via an institution.
References
Kakizoe T (2006) Development and progression of urothelial carcinoma. Cancer Sci 97:821–828
Messing EM, Catalona M (1998) Urothelial tumors of the urinary tract. In: Walsh PC, Retik AB, Vaughan ED Jr, Wein AJ (eds) Compbell’s urology. W.B.Saunders, Philadelphia, pp 2327–2410
Parkin DM, Bray F, Ferlay J et al (2001) Estimating the world cancer burden: globocan 2000. Int J Cancer 94:153–156
Rosenberg JE, Garroll PR, Small EJ (2005) Update of chemotherapy for advanced bladder cancer. J Urol 174:14–20
Sugano K, Kakizoe T (2006) Genetic alterations in bladder cancer and their clinical applications in molecular tumor staging. Nat Urol Pract 3:642–652
See Also
(2012) Carcinoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 657. doi:10.1007/978-3-642-16483-5_848
(2012) Clonal. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 884. doi:10.1007/978-3-642-16483-5_1219
(2012) Field cancerization. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1406. doi:10.1007/978-3-642-16483-5_2185
(2012) Loss of heterozygosity. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 2075-2076. doi:10.1007/978-3-642-16483-5_3415
(2012) P53. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2747. doi:10.1007/978-3-642-16483-5_4331
(2012) RB1. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3189. doi:10.1007/978-3-642-16483-5_4964
(2012) Transurethral resection. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3775. doi:10.1007/978-3-642-16483-5_5960
(2012) Urothelial carcinoma in situ. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3855. doi:10.1007/978-3-642-16483-5_6125
(2012) Urothelium. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3858. doi:10.1007/978-3-642-16483-5_6129
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer-Verlag Berlin Heidelberg
About this entry
Cite this entry
Kakizoe, T. (2015). Urothelial Carcinoma, Clinical Oncology. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_6124-2
Download citation
DOI: https://doi.org/10.1007/978-3-642-27841-9_6124-2
Received:
Accepted:
Published:
Publisher Name: Springer, Berlin, Heidelberg
Online ISBN: 978-3-642-27841-9
eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences