Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Urothelial Carcinoma

  • Wolfgang A. Schulz
  • Michèle J. Hoffmann
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6123-4



Urothelial carcinoma is a cancer arising from the urothelium, a specialized epithelium lining the urinary tract from the renal pelvis into the urethra, retaining discernible morphological aspects and molecular markers of urothelial cells.


Distribution, Histology, and Clinical Course

Urothelial carcinomas (UCs) arise from the urothelium, an epithelium lining the urinary tract from the renal pelvis into the urethra. Most tumors initiate in the urinary bladder, but some are localized in the urethra, the renal pelvis, and the ureters. Tumors arising in the upper urinary tract are somewhat different with respect to etiology and molecular genetics. Urothelial carcinoma is the most common histological subtype of bladder cancer in most countries, often retaining aspects of normal urothelial differentiation including markers like cytokeratins 7, 13, and 20 and uroplakins. Another histological...


Bladder Cancer Lynch Syndrome Urothelial Carcinoma Tuberous Sclerosis Complex Urothelial Cancer 
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  1. Besatarina A, Cockburn M, Tommasi S (2013) Alterations of DNA methylome in human bladder cancer. Epigenetics 8:1013–1022CrossRefGoogle Scholar
  2. Burger M, Catto JW, Dalbagni G et al (2013) Epidemiology and risk factors of urothelial bladder cancer. Eur Urol 63:234–241CrossRefPubMedGoogle Scholar
  3. Cancer Genome Atlas Research Network (2014) Comprehensive molecular characterization of urothelial bladder carcinoma. Nature 507:315–322CrossRefGoogle Scholar
  4. Knowles MA, Hurst CD (2015) Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity.Google Scholar
  5. Nadal R, Bellmunt J (2014) New treatments for bladder cancer: when will we make progress. Curr Treat Options Oncol 15:99–114CrossRefPubMedGoogle Scholar
  6. Schulz WA, Koutsogiannouli EA, Niegisch G, Hoffmann MJ (2014) Epigenetics of urothelial carcinoma. Methods Mol Biol 1238:183–215Google Scholar
  7. Soloway M, Khoury S (eds) Bladder cancer, 2nd edn. 2nd international consultation on bladder cancer, Vienna. http://www.icud.info/bladdercancer2nd.html

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of UrologyHeinrich Heine UniversityDüsseldorfGermany