Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Urokinase-Type Plasminogen Activator

  • Manfred Schwab
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6120-2




An activator of plasminogen that is distinguished from tissue-type plasminogen activator by its ability to regulate cell behavior and tissue remodeling upon binding to its specific cell surface receptor. Serine proteinase converts plasminogen to enzymatically active plasmin, an anticoagulant. It is overexpressed in a variety of malignant tumors with poor prognosis.



Cell Surface Cancer Research Poor Prognosis Malignant Tumor Specific Cell 
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See Also

  1. (2012) Tissue-type plasminogen activator. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3705. doi: 10.1007/978-3-642-16483-5_5832Google Scholar
  2. Rattenholl A, Steinhoff M, Schneider SW, Görge T (2012) Proteinase-activated receptors. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/ Heidelberg, pp 3095–3096. doi: 10.1007/978-3-642-16483-5_4810Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.German Cancer Research Center (DKFZ)HeidelbergGermany