Definition
Tumors of unknown histogenesis are those in which the normal cell counterpart has not as yet been identified. Recent advances in the molecular understanding of cancer have led to classification of these tumors in terms of differentiation, regardless of their location and the presumed cell of origin.
Characteristics
Tumors are classified as epithelial, mesenchymal, lymphoid, or neuroectodermal depending on their cell of origin. Most tumors show the histopathological features of their normal cellular counterpart and can be classified accordingly. Currently, pathologists are attempting to classify tumors according to their patterns of gene expression and markers of differentiation. An important related discovery is the so-called cancer stem cell, which has the potential to self-renew and form additional cancer cells of a similar phenotype and to give rise to phenotypically diverse cancer cells. These cancer cells can arise from mutational transformation of normal stem cells or...
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References
Fletcher CDM (2013) Diagnostic of tumors, 4th edn. Saunders/Elsevier, Philadelphia, pp 1796–1870
Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F (2013) WHO classification of tumours of soft tissue and bone. International agency for research on Cancer, Lyon, pp 193–232
Goldblum JR, Folpe AL, Weiss SW (2014) Enzinger and Weiss’s soft tissue tumours. In: Malignant soft tissue tumors of uncertain type, 6th edn. Mosby, Philadelphia, pp 1028–1112
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See Also
(2012) Alveolar soft part sarcoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 150. doi:10.1007/978-3-642-16483-5_215
(2012) Capillary hemangioblastoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 640. doi:10.1007/978-3-642-16483-5_830
(2012) Clear cell sarcoma of soft tissue. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 880. doi:10.1007/978-3-642-16483-5_1209
(2012) Epithelioid sarcoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1297. doi:10.1007/978-3-642-16483-5_1965
(2012) Extrarenal rhabdoid tumor. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1370. doi:10.1007/978-3-642-16483-5_2078
(2012) Extraskeletal myxoid chondrosarcoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1370. doi:10.1007/978-3-642-16483-5_2079
(2012) Myxoid tumors. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2446. doi:10.1007/978-3-642-16483-5_3953
(2012) Neoplasms with perivascular epithelioid cell differentiation. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2474. doi:10.1007/978-3-642-16483-5_4012
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y Cajal, S.R., Huguet, P., Romagosa, C. (2015). Uncertain or Unknown Histogenesis Tumors. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_6105-2
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DOI: https://doi.org/10.1007/978-3-642-27841-9_6105-2
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