Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Ubiquitination

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6087-2

Definition

It is the covalent modification of a protein by conjugation to ubiquitin (Fig. 1). Ubiquitin is a small, 76-residue protein found in all eukaryotes. Conjugates are formed through the ligation of the C-terminus of ubiquitin to the ε-amino groups of protein lysine residues. The major, but not sole, function of ubiquitination is to target proteins for degradation by the proteasome. A large number of proteins are substrates for this regulatory pathway. Efficient targeting of proteins for degradation usually involves formation of a multiubiquitin chain on the target protein. Such chains are characterized by specific ubiquitin-ubiquitin linkages.

Keywords

Vascular Endothelial Growth Factor Acute Promyelocytic Leukemia Mantle Cell Lymphoma Fanconi Anemia Arsenic Trioxide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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See Also

  1. (2012) Benign Tumor. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 381. doi:10.1007/978-3-642-16483-5_579Google Scholar
  2. (2012) CYLD. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1036. doi:10.1007/978-3-642-16483-5_1442Google Scholar
  3. (2012) De-ubiquitinating Enzymes. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1104. doi:10.1007/978-3-642-16483-5_1593Google Scholar
  4. (2012) FOS. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1446. doi:10.1007/978-3-642-16483-5_2252Google Scholar
  5. (2012) Glycogen Synthase Kinase-3. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1570. doi:10.1007/978-3-642-16483-5_2448Google Scholar
  6. (2012) JUN. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1929. doi:10.1007/978-3-642-16483-5_3186Google Scholar
  7. (2012) P53. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2747. doi:10.1007/978-3-642-16483-5_4331Google Scholar
  8. (2012) Ubiquitin. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3825. doi:10.1007/978-3-642-16483-5_6083Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Cell BiologyHarvard Medical SchoolBostonUSA