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Ubiquitin Ligase SCF-Skp2

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Encyclopedia of Cancer

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Synonyms

S-phase-kinase-associated protein 2; Skp2; CDK2/cyclin A-associated protein p45; F-box and leucine-rich repeat protein 1; Fbxl1; Fbl1

Definition

The SCF-Skp2 ubiquitin ligase belongs to the multi-subunit RING type of E3 ligases involved in ubiquitin-directed protein degradation of key cell-cycle regulators.

Characteristics

Cell-cycle progression is coordinated by the activation of cyclin-dependent kinases (CDKs), the activities of which are controlled by the ubiquitin-directed degradation of key regulators such as cyclinsand CDK inhibitors (CKIs). Two major classes of ubiquitin ligases, the SCF (Skp1-Cul1-Fbp) and APC/C (anaphase-promoting complex/cyclosome), have a central role in cell-cycle regulation. The SCF complexes are used throughout the cell cycle, whereas the APC/C acts primarily during mitosis and G1 phase. The SCF complex and the APC/C are structurally similar. Each is constituted of common subunits and a variable substrate-recognition subunit: F-box proteins for...

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References

  • Cardozo T, Pagano M (2004) The SCF ubiquitin ligase: insights into a molecular machine. Nat Rev Mol Cell Biol 5(9):739–751

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  • Nakayama KI, Nakayama K (2006) Ubiquitin ligases: cell-cycle control and cancer. Nat Rev Cancer 6(5):369–381

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  • Zhang H, Kobayashi R, Galaktionov K et al (1995) p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. Cell 82(6):915–925

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Author information

Authors and Affiliations

  1. DKFZ, German Cancer Research Center, Heidelberg, Germany

    Frank Westermann

Authors
  1. Frank Westermann
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Corresponding author

Correspondence to Frank Westermann .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2012 Springer-Verlag Berlin Heidelberg

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Westermann, F. (2012). Ubiquitin Ligase SCF-Skp2. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_6086-3

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_6086-3

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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