Tumor Necrosis Factor
The tumor necrosis factor (TNF) family includes TNF alpha (TNFα) and TNF beta (TNFβ), which are among the most important cytokines involved in systemic inflammation, tumor lysis, and initiation of the acute-phase reaction.
More than 100 years ago, Dr. Williams B. Coley used crude bacterial extracts to treat tumor patients. He found that the bacterial extracts had an ability to induce tumor necrosis. While tumors were regressive, patients receiving bacterial extracts also suffered from a severe systematic inflammatory reaction. One of the major inflammatory stimulators now known to cause this reaction was identified in 1975, when a protein factor in the serum of endotoxin-treated animals was found to cause lysis in tumor cells and was therefore named “tumor necrosis factor.” In 1984, TNF gene was isolated and characterized. About the same time, another gene...
KeywordsTumor Necrosis Factor Death Domain Bacterial Extract Ubiquitin Chain Systematic Inflammatory Reaction
- Haas TL, Emmerich CH, Gerlach B, Schmukle AC, Cordier SM, Rieser E, Feltham R, Vince J, Warnken U, Wenger T, Koschny R, Komander D, Silke J, Walczak H (2009) Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol Cell 36(5):831–844CrossRefPubMedGoogle Scholar
- Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I (2011) SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature 471(7340):637–641CrossRefPubMedPubMedCentralGoogle Scholar