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Encyclopedia of Cancer pp 1–4Cite as

Tumor Cell-Induced Platelet Aggregation

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Synonyms

Cancer cell-platelet microemboli; Pathological tumor cell-platelet interaction; Tumor cell-platelet aggregate; Tumor cell-platelet interaction; Tumor-induced platelet aggregation

Definition

Tumor cell-induced platelet aggregation (TCIPA) is the ability of cancer cells to generate crucial molecules or surface receptor molecules that mediate platelet aggregation and accelerate the survival advantages of tumor cells in the vasculature, which is important for distant metastasis of cancer.

Characteristics

Hematogenous metastasis of cancer cells to critical distant organs is one of the major reasons for death in most cancer patients. After invasioninto blood vessels, circulating cancer cells may interact with various vascular cells such as leukocytes, platelets, and endothelial cells that may affect the survival and metastasis of tumor cells. Although normal platelet functions are important to control vascular hemostasis and thrombosis, cancer cells may express many factors which...

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References

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See Also

  • (2012) Cyclooxygenase-2. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1035. doi: 10.1007/978-3-642-16483-5_1435

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  • (2012) Glycoprotein. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1570. doi: 10.1007/978-3-642-16483-5_2451

    Google Scholar 

  • (2012) Thromboxane. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3682. doi: 10.1007/978-3-642-16483-5_5798

    Google Scholar 

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Author information

Authors and Affiliations

  1. Biomedical Science Team, Chang Gung Institute of Technology, Taoyuan, Taiwan

    Mei-Chi Chang

  2. Laboratory of Pharmacology and Toxicology, School of Dentistry, National Taiwan University Hospital and National Taiwan University Medical College, Taipei, Taiwan

    Jiiang-Huei Jeng

Authors
  1. Mei-Chi Chang
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  2. Jiiang-Huei Jeng
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Corresponding author

Correspondence to Mei-Chi Chang .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2014 Springer-Verlag Berlin Heidelberg

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Chang, MC., Jeng, JH. (2014). Tumor Cell-Induced Platelet Aggregation. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_6023-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_6023-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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