Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Tumor Cell-Induced Platelet Aggregation

  • Mei-Chi Chang
  • Jiiang-Huei Jeng
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6023-2



Tumor cell-induced platelet aggregation (TCIPA) is the ability of cancer cells to generate crucial molecules or surface receptor molecules that mediate platelet aggregation and accelerate the survival advantages of tumor cells in the vasculature, which is important for distant metastasis of cancer.


Hematogenous metastasis of cancer cells to critical distant organs is one of the major reasons for death in most cancer patients. After invasioninto blood vessels, circulating cancer cells may interact with various vascular cells such as leukocytes, platelets, and endothelial cells that may affect the survival and metastasis of tumor cells. Although normal platelet functions are important to control vascular hemostasis and thrombosis, cancer cells may express many factors which...


Platelet Aggregation Lewis Lung Carcinoma Cell Vascular Endothelial Growth Factor Release Circulate Cancer Cell Cancer Procoagulant 
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See Also

  1. (2012) Cyclooxygenase-2. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1035. doi: 10.1007/978-3-642-16483-5_1435Google Scholar
  2. (2012) Glycoprotein. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1570. doi: 10.1007/978-3-642-16483-5_2451Google Scholar
  3. (2012) Thromboxane. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3682. doi: 10.1007/978-3-642-16483-5_5798Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Biomedical Science TeamChang Gung Institute of TechnologyTaoyuanTaiwan
  2. 2.Laboratory of Pharmacology and Toxicology, School of DentistryNational Taiwan University Hospital and National Taiwan University Medical CollegeTaipeiTaiwan