Tumor Cell-Induced Platelet Aggregation
Tumor cell-induced platelet aggregation (TCIPA) is the ability of cancer cells to generate crucial molecules or surface receptor molecules that mediate platelet aggregation and accelerate the survival advantages of tumor cells in the vasculature, which is important for distant metastasis of cancer.
Hematogenous metastasis of cancer cells to critical distant organs is one of the major reasons for death in most cancer patients. After invasioninto blood vessels, circulating cancer cells may interact with various vascular cells such as leukocytes, platelets, and endothelial cells that may affect the survival and metastasis of tumor cells. Although normal platelet functions are important to control vascular hemostasis and thrombosis, cancer cells may express many factors which...
KeywordsPlatelet Aggregation Lewis Lung Carcinoma Cell Vascular Endothelial Growth Factor Release Circulate Cancer Cell Cancer Procoagulant
- (2012) Cyclooxygenase-2. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1035. doi: 10.1007/978-3-642-16483-5_1435Google Scholar
- (2012) Glycoprotein. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1570. doi: 10.1007/978-3-642-16483-5_2451Google Scholar
- (2012) Thromboxane. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3682. doi: 10.1007/978-3-642-16483-5_5798Google Scholar