Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Triple-Negative Breast Cancer

  • Benoit Paquette
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5981-2

Synonyms

Definition

Triple-negative breast cancer (TNBC) is a subgroup that accounts for 10–20 % of all breast carcinomas. TNBC is characterized by the absence of three receptors: estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2).

Characteristics

Breast cancer is a heterogeneous disease, encompassing a number of distinct biological entities associated with specific morphological and clinical behavior. Technological developments have allowed to sequence the complete genome of breast cancer and compared a large number of tumor samples. From these, studies have emerged five subtypes: luminal A, luminal B, HER2-enriched, basal-like, and claudin-low.

TNBC is sometime referred to as basal-like tumors, as a majority of basal-like cancers are TNBC and approximately 80 % of TNBC are also basal-like breast cancers. TNBC is also associated with younger patients and high-grade...

Keywords

Breast Cancer Mammary Gland Good Responder TNBC Patient Breast Cancer Radiation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health SciencesUniversité de SherbrookeSherbrookeCanada