Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Kapil Mehta
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5922-3



Tissue transglutaminase (TG2; EC is a ubiquitous and most diverse member of the transglutaminase family of enzymes. TG2 catalyzes calcium-dependent posttranslational modification of proteins by inserting highly stable isopeptide bonds between polypeptide chains or by conjugating polyamines to proteins. In addition, TG2 exhibits GTPase activity and can serve as a signal-transduction G protein. Less studied functions of TG2 include its protein disulfide isomerase and protein kinase activities.


TG2 is a multifunctional protein whose expression in some cell types (e.g., endothelial and smooth muscle cells) is constitutively high. In other cell types, TG2s expression is upregulated via discrete signaling pathways, such as those induced by certain stress factors, inflammatory stimuli, differentiation...


Focal Adhesion Kinase Chemotherapeutic Drug Pancreatic Ductal Adenocarcinoma Protein Disulfide Isomerase Tissue Transglutaminase 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.The University of Texas MD Anderson Cancer CenterHoustonUSA