Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Transduction of Oncogenes

  • Jaquelin P. Dudley
Living reference work entry

Latest version View entry history

DOI: https://doi.org/10.1007/978-3-642-27841-9_5911-3



Retroviruses are RNA-containing viruses that replicate through a DNA intermediate (provirus) using the enzyme reverse transcriptase. During retroviral replication, which requires integration into the host chromosomal DNA for efficient transcription of viral RNA, some retroviruses have acquired specific cellular oncogenes, usually with multiple modifications and often with the loss of trans-acting viral functions. Inclusion of one or more oncogenes in the viral genome then imparts transforming activity on the recombinant virus independent of the site of integration in the cellular genome.


Identification of Cellular Oncogenes

In 1911, Peyton Rous described the isolation of a virus that caused fibrosarcomas in chickens. The Rous sarcoma virus (RSV) subsequently was shown to transform chicken embryos and the surrounding membranes and formed small tumors on the chorioallantoic membrane in proportion to the...


Internal Ribosome Entry Site Rous Sarcoma Virus Severe Combine Immune Deficiency Proviral Integration Cellular Oncogene 
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  1. An W, Telesnitsky A (2004) Human immunodeficiency virus type 1 transductive recombination can occur frequently and in proportion to polyadenylation signal readthrough. J Virol 78:3419–3428CrossRefPubMedPubMedCentralGoogle Scholar
  2. Hacein-Bey-Abina S et al (2014) A modified gamma-retrovirus vector for X-linked severe combined immunodeficiency. New England J Med 371:1407–1417CrossRefGoogle Scholar
  3. Nevins JR (2001) Cell transformation by viruses. In: Knipe DM, Howley PM (eds) Fundamental virology, 4th edn. Lippincott William & Wilkins, Philadelphia, pp 245–283Google Scholar
  4. Swain A, Coffin JM (1992) Mechanism of transduction by retroviruses. Science 255:841–855CrossRefPubMedGoogle Scholar
  5. Swanstrom R, Parker RC, Varmus HE et al (1983) Transduction of a cellular oncogene: the genesis of Rous Sarcoma Virus. Proc Natl Acad Sci U S A 80:2519–2523CrossRefPubMedPubMedCentralGoogle Scholar

See Also

  1. (2012) Endogenous Retrovirus. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1232. doi:10.1007/978-3-642-16483-5_1879Google Scholar
  2. (2012) Retrovirus. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 3296–3297. doi:10.1007/978-3-642-16483-5_5084Google Scholar
  3. (2012) Reverse Transcriptase. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3297. doi:10.1007/978-3-642-16483-5_5086Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Department of Molecular Biosciences and Institute for Cellular and Molecular BiologyThe University of Texas at AustinAustinUSA