Tight junctions (TJs) are the apicalmost intercellular structures in epithelial and endothelial cells, playing central roles in the formation of cell polarity and functioning as major determinants of paracellular permeability. Cancer cells often exhibit loss of functional TJs, and decreased or impaired TJ formation has been reported for various types of cancer. Disruption of the TJ structure is associated with cancer development, which is causally involved in malignant phenotypes. Endothelial TJs of the host are believed to be the key apparatus to prevent blood-borne metastasis.
KeywordsVascular Endothelial Growth Factor Paracellular Permeability Salivary Gland Epithelial Cell Apical Junctional Complex Occludin Expression
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