Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Thyroid Carcinogenesis

  • Hartmut M. Rabes
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5806-2


Malignant transformation of thyroid follicle-lining epithelial cells and progression to a clinically manifest thyroid carcinoma. Thyrocytes, embryologically derived from the primitive pharynx, produce thyroid hormones and are thus involved in the regulation of metabolic pathways. Malignant transformation of these cells gives rise to various types of differentiated and undifferentiated thyroid carcinomas. In contrast, medullary carcinomas (5–15 % of all thyroid carcinomas) originate from calcitonin-producing neural crest-derived C cells and form a separate entity.


The main groups of nonmedullary epithelial thyroid carcinomas include:
  • Follicular carcinoma (<20 % of all thyroid carcinomas), composed of closely packed follicles lined by cuboidal or columnar cells with dark-staining round nuclei and eosinophilic cytoplasm. Capsular and/or vascular invasion, missing in follicular adenoma, is crucial for diagnosis of follicular carcinoma. The tumor spreads via the...


Thyroid Carcinoma Papillary Thyroid Carcinoma Papillary Carcinoma Follicular Carcinoma Follicular Adenoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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See Also

  1. (2012) GSP. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1609. doi: 10.1007/978-3-642-16483-5_2528Google Scholar
  2. (2012) Loss of Heterozygosity. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 2075-2076. doi:10.1007/978-3-642-16483-5_3415Google Scholar
  3. (2012) TSH Receptor. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 3786–3787. doi:10.1007/978-3-642-16483-5_6002Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Institute of PathologyUniversity of MunichMunichGermany