Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Thymidine Phosphorylase

  • Masakazu Toi
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5800-2



TP is a nucleoside metabolism enzyme involved in the maintenance of healthy mitochondria and balanced nucleoside triphosphate pool for DNA replication and repair. TP provides multiple cellular biological functions such as stimulation of angiogenesis and antiapoptosis.


TP was purified in the mid-1970s from both Escherichia coli and Salmonella as a nucleoside metabolism enzyme; it is a homodimer of 45 kDa subunits. In the middle of the 1980s, a molecule exhibited angiogenic activity was extracted from human platelets and named PD-ECGF. Subsequently, it was discovered that 2-deoxy- d-ribose (2-DDR), a thymidine metabolite, stimulates chemotaxis of the endothelium and angiogenesis, and then it was clarified that PD-ECGF had TP activity and these two molecules were the same. Somatic mitochondrial DNA point mutations with TP deficiencies result in mitochondrial neurogastrointestinal...


Vascular Endothelial Growth Factor Focal Adhesion Kinase Thymidine Phosphorylase Endothelial Cell Migration Cancer Stroma 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Surgery (Breast Surgery)Graduate School of Medicine, Kyoto UniversityKyotoJapan