Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Bingliang Fang
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5768-2



Thiazolidines are a group of synthetic compounds that can selectively induce G2/M arrest (cell cycle targets for cancer therapy) and apoptosis in cancer cells. They were identified as potential anticancer agents by screening a chemical library for compounds that can kill paclitaxel-sensitive and paclitaxel-resistant cancer but not normal cells. The representatives are 5-[(4-methylphenyl)methylene]-2-(phenylamino)-4(5H)-thiazoloneand 5-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3- thiazolidine. Chemically, the compounds contain three ring structures, a middle oxothiazolidine ring connected with two benzyl rings, one on each side. Several of those compounds can effectively inhibit the growth of human lung, colon, breast, ovary, and prostate cancer cell lines. Treating cancer cells with thiazolidine compounds can induce cell cycle arrest in the G2/M phase and apoptosis, activating caspase-3, caspse-8, and caspase-9 and causing the release of...


Cancer Cell Vascular Endothelial Growth Factor Cell Cycle Arrest Prostate Cancer Cell Line Induce Cell Cycle Arrest 
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  1. Teraishi F, Wu S, Sasaki J et al (2005a) P-glycoprotein-independent apoptosis induction by a novel synthetic compound, 5-[(4-methylphenyl) methylene]-2-(phenylamino)-4(5H)-thiazolone (MMPT). J Pharmacol Exp Ther 314:355–362CrossRefGoogle Scholar
  2. Teraishi F, Wu S, Zhang L et al (2005b) Identification of a novel synthetic thiazolidine compound capable of inducing c-Jun N-terminal kinase-dependent apoptosis in human colon cancer cells. Cancer Res 65:6380–6387CrossRefPubMedPubMedCentralGoogle Scholar

See Also

  1. (2012) C-Jun N-Terminal Kinase (JNK). In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 873. doi: 10.1007/978-3-642-16483-5_1193Google Scholar
  2. (2012) G2/M Arrest. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1484. doi: 10.1007/978-3-642-16483-5_2465Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Thoracic and Cardiovascular SurgeryThe University of Texas M. D. Anderson Cancer CenterHoustonUSA