Thiazolidines are a group of synthetic compounds that can selectively induce G2/M arrest (cell cycle targets for cancer therapy) and apoptosis in cancer cells. They were identified as potential anticancer agents by screening a chemical library for compounds that can kill paclitaxel-sensitive and paclitaxel-resistant cancer but not normal cells. The representatives are 5-[(4-methylphenyl)methylene]-2-(phenylamino)-4(5H)-thiazoloneand 5-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3- thiazolidine. Chemically, the compounds contain three ring structures, a middle oxothiazolidine ring connected with two benzyl rings, one on each side. Several of those compounds can effectively inhibit the growth of human lung, colon, breast, ovary, and prostate cancer cell lines. Treating cancer cells with thiazolidine compounds can induce cell cycle arrest in the G2/M phase and apoptosis, activating caspase-3, caspse-8, and caspase-9 and causing the release of...
KeywordsCancer Cell Vascular Endothelial Growth Factor Cell Cycle Arrest Prostate Cancer Cell Line Induce Cell Cycle Arrest
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