Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Testicular Cancer

  • Axel Heidenreich
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5737-2



About 90 % of all testicular tumors are malignant germ cell tumors, and the rest comprise benign tumors deriving from Leydig and Sertoli cells and other interstitial components. Testicular germ cell tumors originate from totipotent primordial germ cells, which undergo neoplastic transformation as a result of a number of endogenous, exogenous, hormonal, and genetic, as well as environmental, events. The neoplastic process results in the development of preinvasive carcinoma in situ (CIS) or TIN representing the common precursor for all testicular germ cell tumors, except spermatocytic seminoma.


Testicular cancer represents the most common malignant tumor in young men in the age group of 20–40 years. In 1994, ∼6,800 new cases of testicular cancer were diagnosed in the USA. There are striking differences in TC incidences around the world, with the highest...


Germ Cell Tumor Testicular Cancer Testicular Germ Cell Tumor Mature Teratoma Germ Cell Cancer 
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  1. Albers P, Albrecht W, Algaba F, Bokemeyer C, Cohn-Cedermark G, Fizazi K, Horwich A, Laguna MP, Nicolai N, Oldenburg J (2015) Guidelines on testicular cancer: 2015 update. Eur Urol 68(6):1054–1068CrossRefPubMedGoogle Scholar
  2. Beyer J, Albers P, Altena R, Aparicio J, Bokemeyer C, Busch J, Cathomas R, Cavallin-Stahl E, Clarke NW, Claßen J, Cohn-Cedermark G, Dahl AA, Daugaard G, De Giorgi U, De Santis M, De Wit M, De Wit R, Dieckmann KP, Fenner M, Fizazi K, Flechon A, Fossa SD, Germá Lluch JR, Gietema JA, Gillessen S, Giwercman A, Hartmann JT, Heidenreich A, Hentrich M, Honecker F, Horwich A, Huddart RA, Kliesch S, Kollmannsberger C, Krege S, Laguna MP, Looijenga LH, Lorch A, Lotz JP, Mayer F, Necchi A, Nicolai N, Nuver J, Oechsle K, Oldenburg J, Oosterhuis JW, Powles T, Rajpert-De Meyts E, Rick O, Rosti G, Salvioni R, Schrader M, Schweyer S, Sedlmayer F, Sohaib A, Souchon R, Tandstad T, Winter C, Wittekind C (2013) Maintaining success, reducing treatment burden, focusing on survivorship: highlights from the third European consensus conference on diagnosis and treatment of germ-cell cancer. Ann Oncol 24(4):878–888CrossRefPubMedPubMedCentralGoogle Scholar
  3. Cavalli F, Manfardini S, Pizzocaro G (1980) Report on the international workshop on staging and treatment of testicular cancer. Eur J Cancer 6:1367–1372CrossRefGoogle Scholar
  4. Daneshmand S, Albers P, Fosså SD, Heidenreich A, Kollmannsberger C, Krege S, Nichols C, Oldenburg J, Wood L (2012) Contemporary management of postchemotherapy testis cancer. Eur Urol 62(5):867–876CrossRefPubMedGoogle Scholar
  5. Fung C, Fossa SD, Williams A, Travis LB (2015) Long-term morbidity of testicular cancer treatment. Urol Clin North Am 42(3):393–408CrossRefPubMedGoogle Scholar
  6. Heidenreich A, Srivastava S, Moul JW et al (2000) Molecular genetic parameters in pathogenesis and prognosis of testicular germ cell tumors. Eur Urol 37:121–135CrossRefPubMedGoogle Scholar
  7. International Germ Cell Consensus Classification Group (1997) A prognostic factor-based staging system for metastatic germ cell cancers. J Clin Oncol 15:594–603Google Scholar
  8. Oldenburg J, Fosså SD, Nuver J, Heidenreich A, Schmoll HJ, Bokemeyer C, Horwich A, Beyer J, Kataja V; ESMO Guidelines Working Group (2013) Testicular seminoma and non-seminoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 24(Suppl 6):vi125–32Google Scholar
  9. Schmoll HJ, Souchon R, Krege S et al (2004) European consensus on diagnosis and treatment of germ cell cancer: a report of the European Germ Cell Cancer Consensus Group (EGCCCG). Ann Oncol 15:1377–1399CrossRefPubMedGoogle Scholar
  10. Skakkebaek NE, Bertlesen JG, Giwercman A et al (1987) Carcinoma in situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytic seminoma. Int J Androl 10:19–28CrossRefPubMedGoogle Scholar

See Also

  1. (2012) Germ Cell Tumors. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1541. doi: 10.1007/978-3-642-16483-5_6905Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Division of Oncological Urology, Department of UrologyUniversity of KölnKölnGermany