Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Tensional Homeostasis

  • Inkyung Kang
  • Valerie M. Weaver
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5727-2

Definition

A mechano-regulatory network that integrates physical and biochemical cues from the tissue microenvironment through mechano-responsive elements such as transmembrane integrins to evoke cytoskeletal reorganization and actomyosin contractility, thereby altering signal transduction and gene expression to modulate cell and tissue phenotype.

Characteristics

Cells and tissues experience and respond to externally applied mechanical force through mechano-responsive elements that influence signal transduction and result in the generation of reciprocal intracellular force or contractility. The types of mechanical stress a cell can experience include compressive or tensile stress which is applied perpendicular to the surface of the cell and shear stress which is applied parallel to the surface of the cell. For example, osteoblasts and chondrocytes within bone and cartilage are subjected to compressive force induced by walking, lung alveolar cells experience tensile load resulting from...

Keywords

Focal Adhesion Kinase Focal Adhesion Mammographic Density Actomyosin Contractility Integrin Adhesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of SurgeryUniversity of CaliforniaSan FranciscoUSA