Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Gertraud Orend
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5725-2



Tenascin-C is the founding member of a family of extracellular matrix glycoproteins comprising tenascin-X, tenascin-R, and tenascin-W in addition to tenascin-C. Its name has been created by Ruth Chiquet-Ehrismann (1986) and represents a combination of the Latin verbs “tenere” (to hold) and “nasci” (to grow, develop, to be born), which provided the roots of the English words “tendon” and “nascent,” and reflects the location and developmental expression of the protein observed at that time.


Tenascin-C is part of a tumor-specific stroma of most solid cancers and plays a role in enhancing proliferation, angiogenesis, and metastasisduring tumorigenesis. Moreover, research data support the possibility that tenascin-C contributes to cancer formation via interference with genomic stability, by blocking the immunosurveillance and by...


Epidermal Growth Factor Receptor Hepatocyte Growth Factor Focal Adhesion Kinase Laryngeal Carcinoma Fibronectin Type 
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© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Clinical and Biological SciencesInstitute of Biochemistry and Genetics, Center for Biomedicine, DKBW, University of BaselBaselSwitzerland