Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Tenascin-C

  • Gertraud Orend
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5725-2

Synonyms

Definition

Tenascin-C is the founding member of a family of extracellular matrix glycoproteins comprising tenascin-X, tenascin-R, and tenascin-W in addition to tenascin-C. Its name has been created by Ruth Chiquet-Ehrismann (1986) and represents a combination of the Latin verbs “tenere” (to hold) and “nasci” (to grow, develop, to be born), which provided the roots of the English words “tendon” and “nascent,” and reflects the location and developmental expression of the protein observed at that time.

Characteristics

Tenascin-C is part of a tumor-specific stroma of most solid cancers and plays a role in enhancing proliferation, angiogenesis, and metastasisduring tumorigenesis. Moreover, research data support the possibility that tenascin-C contributes to cancer formation via interference with genomic stability, by blocking the immunosurveillance and by...

Keywords

Epidermal Growth Factor Receptor Hepatocyte Growth Factor Focal Adhesion Kinase Laryngeal Carcinoma Fibronectin Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Chiquet-Ehrismann R, Chiquet M (2003) Tenascins: regulation and putative functions during pathological stress. J Pathol 200:488–499CrossRefPubMedGoogle Scholar
  2. Jones PL, Jones FS (2000) Tenascin-C in development and disease: gene regulation and cell function. Matrix Biol 19:581–596CrossRefPubMedGoogle Scholar
  3. Orend G (2005) Potential oncogenic action of tenascin-C in tumorigenesis. Int J Biochem Cell Biol 37:1066–1083CrossRefPubMedGoogle Scholar
  4. Orend G, Chiquet-Ehrismann R (2006) Tenascin-C induced signaling in cancer. Cancer Lett 244:143–163CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Clinical and Biological SciencesInstitute of Biochemistry and Genetics, Center for Biomedicine, DKBW, University of BaselBaselSwitzerland