Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Robert W. Sobol
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5723-3


Base Excision Repair MGMT Expression MGMT Protein Epigenetic Gene Silence MGMT Promoter Hypermethylation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.


  1. Almeida KH, Sobol RW (2007) A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification. DNA Repair 6:695–711PubMedCentralCrossRefPubMedGoogle Scholar
  2. Gerson SL (2004) MGMT: its role in cancer aetiology and cancer therapeutics. Nat Rev Cancer 4:296–307CrossRefPubMedGoogle Scholar
  3. Jiricny J (2006) The multifaceted mismatch-repair system. Nat Rev Mol Cell Biol 7:335–346CrossRefPubMedGoogle Scholar
  4. Newlands ES, Stevens MF, Wedge SR et al (1997) Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials. Cancer Treat Rev 23:35–61CrossRefPubMedGoogle Scholar
  5. Wang JY, Edelmann W (2006) Mismatch repair proteins as sensors of alkylation DNA damage. Cancer Cell 9:417–418CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.University of South Alabama Mitchell Cancer InstituteMobileUSA