Skip to main content
SpringerLink
Log in

Temozolomide

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

  • 90 Accesses

Synonyms

3,4-dihydro-3-methyl-4-oxoimidazo [5,1-d]-as-tetrazine-8-carboxamide; 3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide; 3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide; 3-Methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide; 3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetraazine-8-carboxamide; 8-Carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one; 85622-93-1; AIDS-129717; BRN-5547136; CCRG-81045; Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-; LS-80558; M&B 39831; Methazolastone; NCI60_003316; NSC362856; SCH52365; Temodal; Temodar; Temoget; TMZ

Definition

TMZ is a chemotherapeutic DNA-alkylating agent of the imidazotetrazine class.

IUPAC name = 3-methyl-2-oxo-1,3,4,5,8-pentazabicyclo[4.3.0]nona-4,6,8-triene-7-carbo oxamide

CAS number = 85622-93-1

MW = 194.151 g/mol

Chemical formula = C6H6N6O2

PubChem Compound information – CID #5394: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • Almeida KH, Sobol RW (2007) A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification. DNA Repair 6:695–711

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Gerson SL (2004) MGMT: its role in cancer aetiology and cancer therapeutics. Nat Rev Cancer 4:296–307

    Article  CAS  PubMed  Google Scholar 

  • Jiricny J (2006) The multifaceted mismatch-repair system. Nat Rev Mol Cell Biol 7:335–346

    Article  CAS  PubMed  Google Scholar 

  • Newlands ES, Stevens MF, Wedge SR et al (1997) Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials. Cancer Treat Rev 23:35–61

    Article  CAS  PubMed  Google Scholar 

  • Wang JY, Edelmann W (2006) Mismatch repair proteins as sensors of alkylation DNA damage. Cancer Cell 9:417–418

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University of South Alabama Mitchell Cancer Institute, 1660 Springhill Avenue, Mobile, AL, USA

    Robert W. Sobol

Authors
  1. Robert W. Sobol
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Robert W. Sobol .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this entry

Cite this entry

Sobol, R.W. (2014). Temozolomide. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_5723-3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-27841-9_5723-3

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Search

Navigation