Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Taxotere

  • Edward L. Schwartz
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5691-2

Synonyms

Definition

Taxotere is a widely used cancer chemotherapeutic drug with well-documented clinical antitumor activity against a range of human cancers, including breast, lung, prostate, and ovarian cancers. It is a semisynthetic molecule belonging to the taxane family and is closely related chemically and pharmacologically to the naturally occurring drug Taxol (paclitaxel). Taxotere binds to the β-tubulin component of microtubules, a key cytoskeletal protein in cells, and stabilizes the structure of the microtubule polymer, prevents its disassembly, and suppresses microtubule dynamics. These actions interfere with a number of cellular functions in which the microtubules are involved.

Characteristics

Chemistry

The antitumor activity of the taxanes was first observed in preclinical models using a crude extract of the bark of the Pacific yew tree Taxus brevifolia, and Taxol was subsequently (1971) identified as the active constituent. Both Taxotere and Taxol are...

Keywords

Microtubule Assembly Tubulin Isotype Factor Vascular Endothelial Growth Factor Pruritic Maculopapular Rash Oxetan Ring 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Bhalla KN (2003) Microtubule-targeted anticancer agents and apoptosis. Oncogene 22:9075–9086CrossRefPubMedGoogle Scholar
  2. Hotchkiss KA, Ashton AW, Mahmood R et al (2002) Inhibition of endothelial cell function in vitro and angiogenesis in vivo by docetaxel (taxotere): association with impaired repositioning of the microtubule organizing center. Mol Cancer Ther 1:1191–1200PubMedGoogle Scholar
  3. Montero A, Fossella F, Hortobagyi G et al (2005) Docetaxel for treatment of solid tumours: a systematic review of clinical data. Lancet Oncol 6:229–239CrossRefPubMedGoogle Scholar
  4. Ringel I, Horwitz SB (1990) Studies with RP56976 (Taxotere): a semisynthetic analog of taxol. J Natl Cancer Inst 83:288–291CrossRefGoogle Scholar
  5. Verweij J, Clavel M, Chevalier B (1994) Paclitaxel (Taxol) and docetaxel (Taxotere): not simply two of a kind. Ann Oncol 5:495–505PubMedGoogle Scholar

See Also

  1. (2012) Endothelial cells. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p. 1251. doi: 10.1007/978-3-642-16483-5_1896Google Scholar
  2. (2012) Integrin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p. 1884. doi: 10.1007/978-3-642-16483-5_3084Google Scholar
  3. (2012) Microtubules. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p. 2312. doi: 10.1007/978-3-642-16483-5_3740Google Scholar
  4. (2012) Mitotic spindle. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p. 2348. doi: 10.1007/978-3-642-16483-5_3782Google Scholar
  5. (2012) Paresthesia. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p. 2788. doi: 10.1007/978-3-642-16483-5_4390Google Scholar
  6. (2012) Taxane. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 3614. doi: 10.1007/978-3-642-16483-5_5689Google Scholar
  7. (2012) Tubulin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p. 3792. doi: 10.1007/978-3-642-16483-5_6011Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Medicine (Oncology)Albert Einstein College of MedicineBronxUSA