Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Taxol

  • Spyros D. Georgatos
  • Panayiotis A. Theodoropoulos
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5690-2

Definition

Taxol (paclitaxel) was first isolated in 1971 from a crude extract of Taxus brevifolia, a scarce, slow-growing yew plant found in the forests of the Pacific Northwest. It is a diterpenoid containing the characteristic taxane ring (Fig. 1). Total chemical synthesis of this compound was achieved in 1994, opening the way for the production of various analogues. Currently, taxol is commercially prepared by hemisynthesis, in which a synthetic side chain is attached to natural products isolated from the needles of Taxus plants. Enzymatic conversion of various taxanes to 10-deacetylbaccatin III (a precursor for taxol hemisynthesis) has been reported.

Keywords

Vinca Alkaloid Taxane Class Signal Transduction Machinery Total Chemical Synthesis Sorangium Cellulosum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

References

  1. Haldar S, Basu A, Croce CM (1997) Bcl-2 is the guardian of microtubule integrity. Cancer Res 57:229–233PubMedGoogle Scholar
  2. Nicolaou KC, Yang Z, Liu JJ et al (1994) Total synthesis of taxol. Nature 367:630–634CrossRefPubMedGoogle Scholar
  3. Rodi DJ, Janes RW, Sanganee HJ et al (1999) Screening of a library of phage-displayed peptides identifies human bcl-2 as a taxol-binding protein. J Mol Biol 285:197–203CrossRefPubMedGoogle Scholar
  4. Rowinsky EK, Donehower RS (1995) Paclitaxel (Taxol). N Engl J Med 332:1004–1014CrossRefPubMedGoogle Scholar
  5. Theodoropoulos PA, Polioudaki H, Kostaki O et al (1999) Taxol affects nuclear lamina and pore complex organization and inhibits import of karyophilic proteins into the cell nucleus. Cancer Res 59:4625–4633PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Spyros D. Georgatos
    • 1
  • Panayiotis A. Theodoropoulos
    • 1
  1. 1.Department of Basic SciencesThe University of Crete, School of MedicineHeraklionGreece