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Targeted Drug Delivery

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

  • 56 Accesses

Synonyms

Drug targeting; Site-specific drug delivery

Definition

Targeted drug delivery is to site specifically deliver or activate the therapeutic compounds in tumor. Thus, the targeted drug delivery is expected to enhance drug efficacy by increasing local active drug concentration in tumor and to decrease side effect by minimizing drug exposure in normal tissues.

Characteristics

Anticancer drugs possess a greater potential of toxicity and much narrower therapeutic index than any other categories of medication. Chemotherapy is often dose and toxicity limited. A delicate dose regimen is usually required to balance drug efficacy, drug toxicity, and drug resistance; a high dose might cause toxicity while a low dose might induce drug resistance. In addition, anticancer drugs are usually designed to act on the fast proliferating cancercells. However, rapid proliferation is also the feature of some normal cells such as the bone marrow, hair follicles, and intestinal epithelium. Although...

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References

  • Brannon-Peppas L, Blanchette JO (2004) Nanoparticle and targeted systems for cancer therapy. Adv Drug Deliv Rev 56:1649–1659

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  • Hood JD, Bednarski M, Frausto R et al (2002) Tumor regression by targeted gene delivery to the neovasculature. Science 296:2404–2407

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See Also

  • (2012) CD33. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 698. doi: 10.1007/978-3-642-16483-5_927

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  • (2012) Doxorubicin. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1159. doi: 10.1007/978-3-642-16483-5_1722

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  • (2012) Endothelial Cells. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1251. doi: 10.1007/978-3-642-16483-5_1896

    Google Scholar 

  • (2012) Folate Receptor Alpha. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1440. doi: 10.1007/978-3-642-16483-5_6960

    Google Scholar 

  • (2012) Liposomes. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2063. doi: 10.1007/978-3-642-16483-5_3388

    Google Scholar 

  • (2012) Methotrexate. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2274. doi: 10.1007/978-3-642-16483-5_3680

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pharmaceutical Sciences, University of Michigan, 48104, Ann Arbor, MI, USA

    Duxin Sun

Authors
  1. Duxin Sun
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Corresponding author

Correspondence to Duxin Sun .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Sun, D. (2015). Targeted Drug Delivery. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_5674-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_5674-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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