Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Tankyrases

  • Hiroyuki Seimiya
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5667-2

Synonyms

Definition

Tankyrases are members of the poly(ADP-ribose) polymerase (Parp) family that regulate telomere length in telomerase-positive human cells. There are two related homologues, tankyrase-1 and tankyrase-2. Tankyrase-1 is a protein of 1,327 amino acids and 142 kDa. The gene maps to 8p22–p23. Tankyrase-2 is a protein of 1,166 amino acids and 127 kDa. The gene maps to 10q23. Tankyrase-1 is relatively abundant in reproductive tissues (i.e., testis and ovary), whereas tankyrase-2 exhibits rather ubiquitous expression.

Characteristics

Structure

Tankyrase-1 has four characteristic domains: HPS, ANK, SAM, and PARP. The N-terminal HPS domain is a homopolymeric run of histidine, proline, and serine residues, the functional significance of which is unknown. The ANK domain is composed of a long stretch of 24 ANK repeats, providing a platform for protein-protein interactions. Distinct from those of ankyrins, tankyrase-1’s...

Keywords

Telomere Length PARP Inhibitor Telomere Elongation Sterile Alpha Motif Acceptor Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Chang P, Coughlin M, Mitchison TJ (2005) Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function. Nat Cell Biol 7:1133–1139CrossRefPubMedGoogle Scholar
  2. Dynek JN, Smith S (2004) Resolution of sister telomere association is required for progression through mitosis. Science 304:97–100CrossRefPubMedGoogle Scholar
  3. Seimiya H (2006) The telomeric PARP, tankyrases, as targets for cancer therapy. Br J Cancer 94:341–345CrossRefPubMedPubMedCentralGoogle Scholar
  4. Seimiya H, Muramatsu Y, Ohishi T et al (2005) Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics. Cancer Cell 7:25–37CrossRefPubMedGoogle Scholar
  5. Smith S, Giriat I, Schmitt A et al (1998) Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science 282:1484–1487CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Division of Molecular Biotherapy, Cancer Chemotherapy CenterJapanese Foundation for Cancer ResearchKoto-kuJapan