BCL3 stands for B-cell leukemia/lymphoma 3. The BCL3 gene is a proto-oncogene mapping to chromosomal band 19q13. It encodes a phosphoprotein of 446 amino acids exhibiting an apparent molecular weight between 47 and 60 kDa. BCL3 is an IκB-like protein that primarily functions as a transcriptional cofactor, especially in cooperation with NF-κB (nuclear factor κB).
Structure and Molecular Function
As its main structural feature, BCL3 protein exhibits seven so-called ankyrin repeat elements in its central domain. This structure is characteristic of the IκB family of proteins. Ankyrin repeats are tandemly arranged modules of about 33 amino acids. Through these motifs, IκB proteins interact with and modulate the activity of NF-κB transcription factors. The NF-κB family consists of five members called RelA, RelB, c-Rel, p50, and p52. These subunits form various homo- and heterodimers that regulate the transcription of target genes by binding to specific (κB) sites...