Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

BCL3

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_565-2

Definition

BCL3 stands for B-cell leukemia/lymphoma 3. The BCL3 gene is a proto-oncogene mapping to chromosomal band 19q13. It encodes a phosphoprotein of 446 amino acids exhibiting an apparent molecular weight between 47 and 60 kDa. BCL3 is an IκB-like protein that primarily functions as a transcriptional cofactor, especially in cooperation with NF-κB (nuclear factor κB).

Characteristics

Structure and Molecular Function

As its main structural feature, BCL3 protein exhibits seven so-called ankyrin repeat elements in its central domain. This structure is characteristic of the IκB family of proteins. Ankyrin repeats are tandemly arranged modules of about 33 amino acids. Through these motifs, IκB proteins interact with and modulate the activity of NF-κB transcription factors. The NF-κB family consists of five members called RelA, RelB, c-Rel, p50, and p52. These subunits form various homo- and heterodimers that regulate the transcription of target genes by binding to specific (κB) sites...

Keywords

Chronic Lymphocytic Leukemia BCL3 Expression Anaplastic Large Cell Lymphoma BCL3 Overexpression BCL3 Phosphorylation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Bates PW, Miyamoto S (2004) Expanded nuclear roles for IκBs. Sci STKE 254:pe48Google Scholar
  2. Viatour P, Merville M-P, Bours V et al (2004) Protein phosphorylation as a key mechanism for the regulation of BCL3 activity. Cell Cycle 3:1498–1501CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Praxis für Naturheilkunde und ganzheitliche TherapieLeipzigGermany