Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Julia M. George
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5631-2


Synucleins are small cytosolic proteins of uncertain function, normally expressed at high levels in the vertebrate nervous system. Increased expression of synuclein proteins, especially γ-synuclein, is associated with progression of a variety of tumors.


The precise function of the synuclein proteins is not well understood. All family members (α-synuclein, SNCA; β-synuclein, SNCB; and γ-synuclein, SNCG) share a conserved domain related to the lipid-binding domains of the exchangeable apolipoproteins, the major lipid transporters in blood. This conserved domain mediates reversible interactions with lipid membranes. α-Synuclein regulates the uptake and incorporation of fatty acids into phospholipids, and mutations in α-synuclein alter the composition of cellular membranes.

Each of the synuclein isoforms possesses a unique tail domain, which may mediate distinct physiological actions. α-Synuclein and β-synuclein are normally expressed in the central nervous...


Burkitt Lymphoma Cell Epigenetic Gene Silence Estrogen Receptor Pathway Mitotic Spindle Checkpoint Burkitt Lymphoma Cell Line 
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  3. Lavedan C (1998) The synuclein family. Genome Res 8:871–880PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Queen Mary University of LondonLondonUK