Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Michele Carbone
  • Haining Yang
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5610-2



A DNA tumor virus (genus Polyomavirus) was found to be a contaminant of Salk and Sabin polio vaccines (1955–1961) that propagates naturally in kidney cell lines of Asian macaque species, specifically the rhesus and African green monkey. SV40 in these species, and related primates, produces no cytopathic effects upon the animals, but the virus injected into hamsters and other rodents causes ependymomas, lymphomas, osteosarcomas, sarcomas, and mesotheliomas. Subsequent research has shown a possible correlation between SV40 (Fig. 1) and human mesotheliomas.


Mesothelial Cell Human Mesothelial Cell Monkey Kidney Cell Line SV40 Genome Rhesus Monkey Kidney Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.


  1. Bocchetta M, Eliasz S, Arakelian De Marco M, Rudzinski J, Zhang L, Carbone M (2008) The SV40 large T Antigen-p53 complexes bind and activate the insulin-like growth factor-I promoter stimulating cell growth. Cancer Res, 68: 1022–1029.Google Scholar
  2. Carbone M (1999) Carbone M (1999) Simian virus 40 and human tumors: It is time to study mechanisms. J Cell Biochem, 76(2):189–193.Google Scholar
  3. Cutrone R, Lednicky J, Dunn G et al (2005) Some oral poliovirus vaccines were contaminated with infectious SV40 after 1961. Cancer Res 65:10273–10279CrossRefPubMedGoogle Scholar
  4. Gazdar AF and Carbone M (2003) Molecular pathogenesis of malignant mesothelioma and its relationship to simian virus 40. Clin Lung Cancer, 5:177–181.Google Scholar
  5. Kroczynska B, Cutrone R, Bocchetta M et al (2006) Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamsters. Proc Natl Acad Sci U S A 103:14128–14133CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.University of Hawaii Cancer CenterHonoluluUSA