Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Surgical Trauma and Cancer Recurrence

  • Wilhelmin M. U. van Grevenstein
  • Casper H. J. van Eijck
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5601-2

Definition

Surgical trauma occurs after every surgical procedure by using traumatic tools, gauzes, and by rubbing the tissue. This causes an inflammatory response during which loads of cytokines and growth factors are produced. These factors will create an outstanding environment where tumor cells can adhere and flourish into a tumor lesion. Understanding the specific mechanism of tumor cell adhesion can lead to develop specific tools to prevent local and distant recurrence in the future.

Characteristics

The process of cancer metastasis could be compared to an exhausting obstacle race, during which the tumor cell has to pass a series of sequential interrelated steps to become a clinically relevant lesion. In distant metastasis, the tumor cell must succeed in invasion, embolization, and survival in the circulation and adhere to a distant capillary endothelium, followed by extravasation and multiplication in another organ. Locoregional tumor recurrence after intra-abdominal seeding or...

Keywords

Reactive Oxygen Species Pancreatic Cancer Mesothelial Cell Surgical Trauma Wound Healing Process 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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  5. van Grevenstein WM, Aalbers AG, Ten Raa S et al (2007) Surgery-derived reactive oxygen species produced by polymorphonuclear leukocytes promote tumor recurrence: studies in an in vitro model. J Surg Res 140:115–120CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Wilhelmin M. U. van Grevenstein
    • 1
  • Casper H. J. van Eijck
    • 1
  1. 1.Department of SurgeryErasmus MCRotterdamThe Netherlands