Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Surgical Trauma and Cancer Recurrence

  • Wilhelmin M. U. van Grevenstein
  • Casper H. J. van Eijck
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5601-2


Surgical trauma occurs after every surgical procedure by using traumatic tools, gauzes, and by rubbing the tissue. This causes an inflammatory response during which loads of cytokines and growth factors are produced. These factors will create an outstanding environment where tumor cells can adhere and flourish into a tumor lesion. Understanding the specific mechanism of tumor cell adhesion can lead to develop specific tools to prevent local and distant recurrence in the future.


The process of cancer metastasis could be compared to an exhausting obstacle race, during which the tumor cell has to pass a series of sequential interrelated steps to become a clinically relevant lesion. In distant metastasis, the tumor cell must succeed in invasion, embolization, and survival in the circulation and adhere to a distant capillary endothelium, followed by extravasation and multiplication in another organ. Locoregional tumor recurrence after intra-abdominal seeding or...


Reactive Oxygen Species Pancreatic Cancer Mesothelial Cell Surgical Trauma Wound Healing Process 
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  1. Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow? Lancet 357(9255):539–545CrossRefPubMedGoogle Scholar
  2. Meager A (1999) Cytokine regulation of cellular adhesion molecule expression in inflammation. Cytokine Growth Factor Rev 10(1):27–39CrossRefPubMedGoogle Scholar
  3. Sugarbaker PH (1991) A perspective on clinical research strategies in carcinoma of the large bowel. World J Surg 15(5):609–616CrossRefPubMedGoogle Scholar
  4. ten Kate M, Hofland LJ, van Grevenstein WM et al (2004) Influence of proinflammatory cytokines on the adhesion of human colon carcinoma cells to lung microvascular endothelium. Int J Cancer 112(6):943–950CrossRefPubMedGoogle Scholar
  5. van Grevenstein WM, Aalbers AG, Ten Raa S et al (2007) Surgery-derived reactive oxygen species produced by polymorphonuclear leukocytes promote tumor recurrence: studies in an in vitro model. J Surg Res 140:115–120CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Wilhelmin M. U. van Grevenstein
    • 1
  • Casper H. J. van Eijck
    • 1
  1. 1.Department of SurgeryErasmus MCRotterdamThe Netherlands