Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Suppressors of Cytokine Signaling

  • Zoran Culig
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5588-2

Synonyms

Definition

Suppressors of cytokine signaling (SOCS) and the cytokine-inducible SH2 protein CIS regulate the responses of various cells to interleukins and other cytokines. They are rapidly induced after treatment with a cytokine. SOCS prevent prolonged activation of the signaling pathway of Janus kinase (JAK)/signal transducer and activator of transcription (STAT).

Characteristics

The SOCS/CIS family has eight members: SOCS-1, SOCS-2, SOCS-3, SOCS-4, SOCS-5, SOCS-6, SOCS-7, and CIS. They are composed of an amino-terminal domain of variable length, central SH2 domain, and a carboxy-terminal 40-amino-acid module known as SOCS box. Expression and function of SOCS-1, SOCS-2, SOCS-3, and CIS were characterized in most studies.

SOCS-1 and SOCS-3 downregulate JAK tyrosine kinase activity due to the presence of an inhibitory region in their amino-terminal domain. SOCS-1 could bind directly to JAK kinase through its SH2 domain, whereas SOCS-3 SH2 domain binds the signal...

Keywords

Chronic Myeloid Leukemia Chronic Myeloid Leukemia Cell Chronic Myeloid Leukemia Cell Line Pituitary Cancer Signal Transduction Subunit Gp130 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Campbell IL (2001) Cytokine-mediated inflammation, tumorigenesis, and disease-associated JAK/STAT/SOCS signaling circuits in the CNS. Brain Res Brain Res Rev 48:166–167CrossRefGoogle Scholar
  2. Heinrich PC, Behrmann I, Haan S et al (2003) Principles of interleukin (IL)-6 type cytokine signaling and its regulation. Biochem J 374:1–20PubMedCentralCrossRefPubMedGoogle Scholar
  3. Jasmin JF, Mercier I, Sotgia F et al (2006) SOCS protein and caveolin-1 as negative regulators of endocrine signaling. Trends Endocrinol Metab 17:150–158CrossRefPubMedGoogle Scholar
  4. Starr R, Hilton DJ (1998) SOCS: suppressors of cytokine signaling. Int J Biochem Cell Biol 30:1081–1085CrossRefPubMedGoogle Scholar
  5. Valentino L, Pierre J (2006) JAK/STAT signal transduction: regulators and implication in hematological malignancies. Biochem Pharmacol 71:713–721CrossRefPubMedGoogle Scholar

See Also

  1. (2012) CAMP. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 603. doi:10.1007/978-3-642-16483-5_788Google Scholar
  2. (2012) Elongin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1217. doi:10.1007/978-3-642-16483-5_1852Google Scholar
  3. (2012) Epigenetic mechanism. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1286. doi:10.1007/978-3-642-16483-5_1945Google Scholar
  4. (2012) Interferon gamma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1888. doi:10.1007/978-3-642-16483-5_3092Google Scholar
  5. (2012) Interleukin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1892. doi:10.1007/978-3-642-16483-5_3094Google Scholar
  6. (2012) JAK. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1923. doi:10.1007/978-3-642-16483-5_3170Google Scholar
  7. (2012) Leukemia. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2005. doi:10.1007/978-3-642-16483-5_3322Google Scholar
  8. (2012) Lymphoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2124. doi:10.1007/978-3-642-16483-5_3463Google Scholar
  9. (2012) Negative feedback mechanism. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2469. doi:10.1007/978-3-642-16483-5_3998Google Scholar
  10. (2012) SH2 domain. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3397. doi:10.1007/978-3-642-16483-5_5280Google Scholar
  11. (2012) SOCS. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3460. doi:10.1007/978-3-642-16483-5_5399Google Scholar
  12. (2012) Src kinase. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3498. doi:10.1007/978-3-642-16483-5_5470Google Scholar
  13. (2012) STAT. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3502. doi:10.1007/978-3-642-16483-5_5481Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of UrologyInnsbruck Medical UniversityInnsbruckAustria