Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Sulforaphane

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5567-2

Synonyms

Definition

Sulforaphane belongs to the isothiocyanate family. It is a hydrolysis product of glucoraphanin, a glucosinolate found in broccoli. Its molecular formula is C6H11NOS2, and its molecular weight is 177.29 Da. Glucoraphanin is also known as 4-methylsufinylbutyl glucosinolate. Sulforaphane is the aglycone breakdown product of glucoraphanin, also known as sulforaphane glucosinolate (SGS). Glucosinolates are beta-thioglucoside-N-hydroxysulfates and are primarily found in cruciferous vegetables (cabbage, broccoli, broccoli sprouts, brussels sprouts, cauliflower, cauliflower sprouts, bok choy, kale, collards, arugula, kohlrabi, mustard, turnip, red radish, and watercress). Young broccoli sprouts and young cauliflower sprouts are especially rich in glucoraphanin. The enzyme myrosinase present in cruciferous vegetables converts glucoraphanin to sulforaphane upon damage to the plant (such...

Keywords

Cruciferous Vegetable Chemical Carcinogenesis Quinone Reductase Mercapturic Acid Chemopreventive Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Bailey GS, Chung F-L, Nishikawa A et al (2004) Animal studies: metabolism cancer-preventive effects, intermediary biomarkers. In: WHO (ed) IARC Handbook on cancer prevention. Cruciferous vegetables, isothiocyanates and indoles, vol 9. IARC, LyonGoogle Scholar
  2. Fahey JW, Zhang Y, Talalay P (1997) Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci 94:10367–10372CrossRefPubMedPubMedCentralGoogle Scholar
  3. Zhang Y, Talalay P, Cho CG et al (1992) A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci 89:2399–2403CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Oncology, Lombardi Comprehensive Cancer CenterGeorgetown University Medical CenterWashingtonUSA