Sulforaphane belongs to the isothiocyanate family. It is a hydrolysis product of glucoraphanin, a glucosinolate found in broccoli. Its molecular formula is C6H11NOS2, and its molecular weight is 177.29 Da. Glucoraphanin is also known as 4-methylsufinylbutyl glucosinolate. Sulforaphane is the aglycone breakdown product of glucoraphanin, also known as sulforaphane glucosinolate (SGS). Glucosinolates are beta-thioglucoside-N-hydroxysulfates and are primarily found in cruciferous vegetables (cabbage, broccoli, broccoli sprouts, brussels sprouts, cauliflower, cauliflower sprouts, bok choy, kale, collards, arugula, kohlrabi, mustard, turnip, red radish, and watercress). Young broccoli sprouts and young cauliflower sprouts are especially rich in glucoraphanin. The enzyme myrosinase present in cruciferous vegetables converts glucoraphanin to sulforaphane upon damage to the plant (such...
KeywordsCruciferous Vegetable Chemical Carcinogenesis Quinone Reductase Mercapturic Acid Chemopreventive Activity
- Bailey GS, Chung F-L, Nishikawa A et al (2004) Animal studies: metabolism cancer-preventive effects, intermediary biomarkers. In: WHO (ed) IARC Handbook on cancer prevention. Cruciferous vegetables, isothiocyanates and indoles, vol 9. IARC, LyonGoogle Scholar