Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Suicide Gene Therapy

  • Manfred Schwab
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5558-2


Refers to the two-step process of delivering a gene to tumor cells that is able to transform a nontoxic prodrug into a toxic metabolite and thus killing the cells. Transfer of a gene which, when expressed in cells, activates a normally nontoxic prodrug to a toxic form.



Tumor Cell Cancer Research Gene Therapy Toxic Metabolite Toxic Form 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.German Cancer Research Center (DKFZ)HeidelbergGermany