Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

B-cell Lymphoma

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_553-7

Synonyms

Definition

B-cell lymphoma is a cancer of the B lymphocytes, a type of cell that forms part of the immune system. Lymphomas are “blood cancers” in lymphoid organs.

Characteristics

B-cell lymphoma is the most common form of hematological malignancy, or “blood cancer,” in the United States. Taken together, lymphomas represent 5.0 % of all cancers in the United States and 55 % of all blood cancers. B-cell lymphomas express B-cell receptor (BCR) (membrane bound antibody) on their surface and B-cell lineage specific markers such as CD19 and CD20. B lymphoma cells often originate in lymph nodes, presenting as an enlargement of the node (a tumor). There are neither early warning signs nor known effective genetic or biochemical markers that can be used for screening purposes. There are two types of B cell lymphomas – Hodgkin’s lymphoma (HL) and Non-Hodgkin’s lymphoma (NHL), which differ in the morphology and phenotype of lymphoma cells and the...

Keywords

Chronic Lymphocytic Leukemia Follicular Lymphoma Mantle Cell Lymphoma Burkitt Lymphoma Gastric Lymphoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Microbiology, Immunology and Molecular GeneticsUniversity of KentuckyLexingtonUSA
  2. 2.Department of Hematology and OncologyCedars-Sinai Medical CenterLos AngelesUSA
  3. 3.Bristol-Myers Squibb & CoPrincetonUSA